Anti-SEL1L antibody ab78298 from Abcam

Product Specs
ItemAnti-SEL1L antibody
CompanyAbcam
Price Pricing Info Supplier Page View Company Product Page
Catalog Numberab78298
Antibody TypePrimary
ApplicationsWestern blot
Conjugate/TagUnconjugated
Quantity100 UG
ClonalityPolyclonal
IsotypeIgG
HostRabbit
Concentration0.2 mg/ml
Gene NameSEL1L
ReactivityHuman
TargetSEL1L

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytesNature communicationsMay 30, 2023Wu SA, Shen C, Wei X, Zhang X, Wang S, Chen X, Torres M, Lu Y, Lin LL, Wang HH, et al.from Dr. Andre Bensadoun, Cornell University and R&D Systems AF7197-SP)31, anti-SEL1L (1:1000, Abcam, ab78298; 1:10,000, homemade)39, anti-HRD1 (1:200, gift from Richard Wojcikiewicz, Syracuse University; 1:1000,

(2) SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING poolNature cell biologyMay 1, 2023Ji Y, Luo Y, Wu Y, Sun Y, Zhao L, Xue Z, Sun M, Wei X, He Z, Wu SA, et al.(1:3,000; 20536-1-AP; Proteintech), IκBα (1:2,000; 9242; Cell Signaling Technology), SEL1L (1:1,000; ab78298; Abcam), BiP (1:5,000; ab21685; Abcam), HRD1 (1:300 (R. Wojcikiewicz) or 1:1,000 (13473-1-AP; Proteintech)),

(3) Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasminProceedings of the National Academy of Sciences of the United States of AmericaJanuary 10, 2023Thepsuwan P, Bhattacharya A, Song Z, Hippleheuser S, Feng S, Wei X, Das NK, Sierra M, Wei J, Fang D, et al.IRE1α (CST 14C10), OS9 (Abcam ab109510), Calnexin (Enzo ADI-SPA-860-D), BiP (CST C50B12), SEL1L (Abcam ab78298), HRD1 (Proteintech 13473-1-AP), CREBH (Kerafast EWS101), Ubiquitin (CST 3933), Flag (Sigma F1804 and

(4) SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver canceriScienceOctober 21, 2022Bhattacharya A, Wei J, Song W, Gao B, Tian C, Wu SA, Wang J, Chen L, Fang D, Qi L.sc-5286); HSP90 (1:1,000, Abcam ab13492); CALNEXIN (1:5000, Enzo ADI-SPA-860-F); SEL1L (1:2,000, Abcam ab78298); HRD1 (1:300, kindly gifted by Dr. Richard Wojcikiewicz, SUNY Upstate Medical University for Western blot

(5) Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectorsLife science allianceDecember 1, 2021Ibe NU, Subramanian A, Mukherjee S.β-Actin (Cat. no. 20536-1-AP; Proteintech), α-Tubulin (Cat. no. 66031-1-Ig; Proteintech), SEL1L (Cat. no. ab78298; Abcam), ABCD3 (Cat. no. 66697-1-Ig; Proteintech), GFP tag (Cat. no. 66002-1-Ig; Proteintech), BiP (Cat.

(6) ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor functioniScienceJuly 23, 2021Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, Katagiri T, Futatsugi A, Shinmyo Y, Kawasaki H, et al.RRID: AB_477193 Mouse-anti-GFP,MBL International,M048-3; RRID: AB_591823 Rabbit-anti-SEL1L,Abcam,ab78298; RRID: AB_2285813 Rabbit-anti-HRD1,Sigma-Aldrich,H7915; RRID: AB_1840939 Rabbit-anti-P-eIF2α,Invitrogen,44-728G;

(7) Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β-selectioneLifeJuly 9, 2021Liu X, Yu J, Xu L, Umphred-Wilson K, Peng F, Ding Y, Barton BM, Lv X, Zhao MY, Sun S, et al.WB Antibody,BiP (C50B12) (Rabbit monoclonal),Cell Signaling,3177 RRID:AB_2119845,(1:200) WB Antibody,Anti-SEL1L (ab78298) (Rabbit polyclonal),Abcam,ab78298 RRID:AB_2285813,(1:200) WB Antibody,β-Actin (13E5) (Rabbit monoclonal),Cell Signaling

(8) Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase ComplexMolecular cellSeptember 3, 2020van de Weijer ML, Krshnan L, Liberatori S, Guerrero EN, Robson-Tull J, Hahn L, Lebbink RJ, Wiertz EJHJ, Fischer R, Ebner D, et al.anti-UBE3C,Abcam,ab226173 Rabbit Monoclonal anti-TMUB1 clone EPR14066,Abcam,ab180586 Rabbit Polyclonal anti-SEL1L,Abcam,"Cat# ab78298, RRID:AB_2285813" Rabbit Monoclonal anti-BiP clone EPR4040(2),Abcam,"Cat# ab108613, RRID:AB_10859806" Rabbit

(9) Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signalingThe Journal of clinical investigationJuly 1, 2020Shrestha N, Liu T, Ji Y, Reinert RB, Torres M, Li X, Zhang M, Tang CA, Hu CA, Liu C, et al.follows: α-tubulin (Santa Cruz Biotechnology Inc., catalog sc-5286; 1:2000); Sel1L (Abcam, catalog ab78298; 1:1000); BiP (Abcam, catalog ab21685; 1:5000), Calnexin (Cell Signaling Technology, catalog 2679; 1:1000),

(10) Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicityeLifeDecember 17, 2019Kitakaze K, Taniuchi S, Kawano E, Hamada Y, Miyake M, Oyadomari M, Kojima H, Kosako H, Kuribara T, Yoshida S, et al.antibodies for immunoblotting were as follows: anti-ATF4 (10835–1-AP, Proteintech, IL, USA), anti-SEL1L (ab78298, Abcam, Cambridge, UK), anti-HERPUD1 (26730S, Cell Signalling Technology, MA, USA), anti-DNAJB9 (13157–1-AP,

(11) Host Gene SEL1L Involved in Endoplasmic Reticulum-Associated Degradation Pathway Could Inhibit Hepatitis B Virus at RNA, DNA, and Protein LevelsFrontiers in MicrobiologyDecember 13, 2019Jinyu Wang et al.Healthcare, USA). The membranes were blocked with 5% skim milk and incubated with antibodies against SEL1L (ab78298, Abcam, UK), EDEM1 (ab209660, Abcam, UK), HBsAg (ab9193, Abcam, UK), HBcAg (ab8639, Abcam, UK), LC3

(12) Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBHThe EMBO JournalNovember 15, 2018Asmita Bhattacharya, Shengyi Sun, Heting Wang, Ming Liu, Qiaoming Long, Lei Yin, Sander Kersten, Kezhong Zhang, Ling QiSanta Cruz sc-7160); BiP (1:1,000; Santa Cruz sc-1051); KDEL (1:500; Abcam ab50601); Sel1L (1:2,000; Abcam ab78298); Os9 (1:5,000; Abcam ab109510); b-actin (1:10,000, Abcam ab20272); Crebh (1:1,000 for Western, 1:100

(13) Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERADNature communicationsSeptember 10, 2018Schultz ML, Krus KL, Kaushik S, Dang D, Chopra R, Qi L, Shakkottai VG, Cuervo AM, Lieberman AP.antibodies: The following primary antibodies were used (antigen, dilution, vendor): Sel1L, 1:1000, Abcam ab78298; Actin, 1:4000, Sigma A5441; NPC1, 1:500 western, Abcam ab36983 (discontinued); NPC1, 1:200 imaging,

(14) Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay DiabetesCell reportsJuly 3, 2018Xu B, Allard C, Alvarez-Mercado AI, Fuselier T, Kim JH, Coons LA, Hewitt SC, Urano F, Korach KS, Levin ER, et al.antibodies were used for immunoblotting: CHOP (2895, Cell Signaling), HRD1 (sc-130889, Santa Cruz), SEL1L (ab78298, Abcam), UBC6e (sc-292491, Santa Cruz), Actin (sc-1616, Santa Cruz) and α-Tubulin (MS-581-P0, Neomarkers).

(15) Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesityThe Journal of clinical investigationMarch 1, 2018Kim GH, Shi G, Somlo DR, Haataja L, Song S, Long Q, Nillni EA, Low MJ, Arvan P, Myers MG Jr, et al.and immunohistochemistry. Antibodies for Western blot were as follows: Sel1L (rabbit, 1:2,000; catalog ab78298, Abcam), BiP/GRP78 (goat, 1:1,000, catalog sc-1051, Santa Cruz Biotechnology Inc.), HSP90 (rabbit, 1:5,000;

(16) ERAD-dependent control of the Wnt secretory factor EviThe EMBO journalFebruary 15, 2018Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, Christianson JC, Boutros M.(rab, NEB, 8081S), VCP (mouse, Abcam, ab11433), FLAG (mouse, Origene, TA50011), SEL1L (mouse, Abcam, ab78298), HSC70 (mouse, Santa Cruz, sc‐7298), and the monoclonal (clone YJ5) Evi antibody (mouse, Biolegend,

(17) ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasisJournal of Clinical InvestigationSeptember 18, 2017Guojun Shi et al.antibodies were used for Western blotting and immunostaining: Sel1L (rabbit, 1:2,000 for Western blotting; ab78298; Abcam); BiP/ GRP78 (goat, 1:1,000 for Western blotting and 1:200 for immuno staining; sc-1051; Santa Cruz Biotechnology Inc

(18) The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell DevelopmentCell ReportsSeptember 1, 2016Yewei Ji, Hana Kim, Liu Yang, Haibo Sha, Christopher A. Roman, Qiaoming Long, Ling Qi

(19) Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formationAutophagyJune 2, 2016Tina Garofalo, Paola Matarrese, Valeria Manganelli, Matteo Marconi, Antonella Tinari, Lucrezia Gambardella, Alberto Faggioni, Roberta Misasi, Maurizio Sorice, Walter Malorni

(20) IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradationNature cell biologyDecember 1, 2015Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, et al.(#3192, 1:2,000), Caspase-3 (#9665, 1:1000), p-T183/Y185-JNK (#9255, 1:2000), from Cell Signaling; Sel1L (ab78298, 1:2,000), OS9 (ab109510, 1:10,000) from Abcam; Hrd1 (NB100-2526, 1:8,000) from Novus Biologicals; Calnexin

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Anti-SEL1L antibody from Abcam

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Anti-SEL1L antibody from Abcam

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